HDAC FAMILY MEMBERS INTERTWINED IN THE REGULATION OF AUTOPHAGY: A DRUGGABLE VULNERABILITY IN AGGRESSIVE TUMOR ENTITIES

HDAC Family Members Intertwined in the Regulation of Autophagy: A Druggable Vulnerability in Aggressive Tumor Entities

The exploitation of autophagy by some Antenna Flylead cancer entities to support survival and dodge death has been well-described.Though its role as a constitutive process is important in normal, healthy cells, in the milieu of malignantly transformed and highly proliferative cells, autophagy is critical for escaping metabolic and genetic stressors

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Effective immuno-therapeutic treatment of Canine Leishmaniasis.

BackgroundCanine Leishmaniasis (CanL) caused by the L.infantum species is one of the biggest threats to the health of the South American canine population.Chemotherapeutics currently used for the treatment of CanL fail to induce a total parasite clearance while inducing numerous side effects.As CanL Neck Gaiter is an immunomodulated disease, the us

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